Recently I started Progesterone, specifically 100mg “bio identical” Oral Micronized taken as suppository (hole poked in the capsule with a safety pin, run under water for a second to soften, then insert with a little lubricant for priming). Without doing a lot of research I noticed some things simply based on the effects I felt […]
Category: AA (Anti-Androgen)
Transgender Breast Development: A lack of data is progress?
There is a trend in transgender research that I’ve noticed – a lack of evidence in either direction is often considered the “gold standard” for clinical practices. This is blatantly absurd. 1. Clinical Review: Breast Development in Trans Women Receiving Cross-Sex Hormones Results: Only few studies with low quality of evidence addressed these topics. The […]
My Hair Recovery Timeline. Aiming for full recovery through biohacking.
This hair recovery timeline is not an endorsement of using Estradiol for hair recovery. Estradiol will dramatically reduce Testosterone production in Testicles and hence serum levels. Estradiol may also permanently sterilize reproductive ability/sperm production (the science is not clear currently). It can also reduce the size of penis/testicles/prostate. My Testosterone levels are well below castration/in […]
Can Estradiol Monotherapy work for you? Will you need antiandrogens?
A lot of people start HRT using blockers such as Spironolactone to suppress Testosterone with the goal of achieving typical cis women levels for optimum feminization. Some people even try a “low and slow” method of antiandrogen monotherapy for several months before starting Estradiol therapy. One frequent question is whether Estradiol Monotherapy (only dosing Estradiol […]
Potential side effects from Finasteride. Is Dutasteride any better?
I was interested in taking Finasteride to see if it helped with hair loss and also to limit localized DHEA to DHT conversion in my body (side stepping Testosterone to DHT conversion). I was prescribed 5mg daily, which is a lot, but I thought it would make side effects very apparent. For me Finasteride was […]
The many strange ways you can regrow long lost hair!
We’ve all been told to preserve what hair we have by being proactive… well I never did that and didn’t care for almost 2 decades as I continued to become increasingly bald. This has led me to investigate various methods of hair recovery and their efficacy. Some of the items listed here are very well […]
Bicalutamide has no established safety guidelines.
When I asked my first HRT (Hormone Replacement Therapy) doctor about trying Bicalutamide 50mg they simply said no. That first doctor was Plume in case you are trying to use Plume to get your hands on Bicalutamide – they will flatly decline for safety concerns. The thing about Bicalutamide is that there are not a […]
My experience with Bicalutamide was not great…
Anecdotal First Hand Experience I had such high hopes for Bicalutamide that I switched doctors primarily to give it a try, because my prior doctor was unwilling. There are no clinical guidelines for safety, so I came up with my own: 1x 50mg Wait 48 hours for any adverse reaction 1x 50mg Wait 48 hours […]
How long does Feminization actually take? Are you stunted?
When reading about how long fat changes take once HRT (Hormone Replacement Therapy) begins (Estradiol, or E2), you’ll find the scale of months or years; both anecdotally and on Wikipedia: 1. Transgender hormone therapy (male-to-female) https://en.wikipedia.org/wiki/Transgender_hormone_therapy_(male-to-female) Effect Time to expectedonset of effect[a] Time to expectedmaximum effect[a][b] Permanency if hormonetherapy is stopped Breast development and nipple/areolar enlargement 2–6 months […]
What are the best Antiandrogens? Limited studies exist.
When I asked my Doctor about whether Spironolactone actually worked, he said it worked well for some people. I mentioned the lack of consensus in studies about efficacy and he simply stated that antiandrogen studies were very limited and pointed to this reference: https://onlinelibrary.wiley.com/doi/pdf/10.1111/cen.14329 5 | CONCLUSIONAntiandrogens are frequently added to estradiol to assist withfeminization and suppression […]