Can Estradiol Monotherapy work for you? Will you need antiandrogens?

A lot of people start HRT using blockers such as Spironolactone to suppress Testosterone with the goal of achieving typical cis women levels for optimum feminization. Some people even try a “low and slow” method of antiandrogen monotherapy for several months before starting Estradiol therapy. One frequent question is whether Estradiol Monotherapy (only dosing Estradiol […]

Potential side effects from Finasteride. Is Dutasteride any better?

I was interested in taking Finasteride to see if it helped with hair loss and also to limit localized DHEA to DHT conversion in my body (side stepping Testosterone to DHT conversion). I was prescribed 5mg daily, which is a lot, but I thought it would make side effects very apparent. For me Finasteride was […]

What are the best Antiandrogens? Limited studies exist.

When I asked my Doctor about whether Spironolactone actually worked, he said it worked well for some people. I mentioned the lack of consensus in studies about efficacy and he simply stated that antiandrogen studies were very limited and pointed to this reference: https://onlinelibrary.wiley.com/doi/pdf/10.1111/cen.14329 5 | CONCLUSIONAntiandrogens are frequently added to estradiol to assist withfeminization and suppression […]

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