A question that comes up often is whether high Estradiol, early Progesterone, or early/high Spironolactone may stunt or limit good breast development. There are limited studies on this topic; however, here are some resources to help shed some light: 1. High Estradiol Gender Analysis has a citation for high Estradiol and resultant poor breast development. … Continue reading Maximum Transfeminine breast development. What is the hard evidence?