When I asked my Doctor about whether Spironolactone actually worked, he said it worked well for some people. I mentioned the lack of consensus in studies about efficacy and he simply stated that antiandrogen studies were very limited and pointed to this reference: https://onlinelibrary.wiley.com/doi/pdf/10.1111/cen.14329 5 | CONCLUSIONAntiandrogens are frequently added to estradiol to assist withfeminization and suppression … Continue reading What are the best Antiandrogens? Limited studies exist.